Current Lab Publications
Mar 22;20(3):e1010899.
Polarity in skin development and cancer. Curr Top Dev Biol. 154:317-336. doi: 10.1016/bs.ctdb.2023.02.003. Epub 2023 Mar 10.PMID: 37100522.
Bara AM, Chen L, Ma C, Underwood J, Moreci RS, Sumigray K, Sun T, Diao Y, Verzi M, Lechler T. 2022. Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut. Development. Dec 1;149(23):dev201251. doi: 10.1242/dev.201251. Epub 2022 Dec 12.PMID: 36504079.
Hair follicle stem cells feel the pressure. Cell Stem Cell. Jan 6;29(1):1-2. doi: 10.1016/j.stem.2021.12.001.PMID: 34995491.
Moreci, R.S. and Lechler, T. 2021. KIF18B is a cell-type specific regulator of spindle orientation in the epidermis. Mol Bio Cell. Aug 25;mbcE21060291. doi: 10.1091/mbc.E21-06-0291.
Kim, Y., Hlavaty, D., Maycock, J., and Lechler, T. 2021. Roles for Ndel1 in keratin organization and desmosome function. Mol Bio Cell. Oct 1;32(20):ar2.doi: 10.1091/mbc.E21-02-0087. Epub 2021 Jul 28.
Lechler, T., and Mapelli, M. 2021. Spindle positioning and its impact on vertebrate tissue architecture and cell fate. Nat Rev Mol Cell Biol. Oct;22(10):691-708. doi: 10.1038/s41580-021-00384-4.Epub 2021 Jun 22.
Ning, W., Muroyama, A., Li, H., and Lechler, T. 2021. Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension. Cell Stem Cell, Mar 4;28(3):436-452.e5
Hlavaty, D. and Lechler, T. 2020. Roles for microtubules in the proliferative and differentiated cells of stratified epithelia. Current Opinions in Cell Biology, Feb;68:98-104
Wang, S., Roy, J.P., Tomlinson, A.J., Wang, E.B., Tsai, Y., Cameron, L., Underwood, J., Spence, J.R., Walton, K.D., Stacker, S.A., Gumucio, D.L., and Lechler, T. 2020. RYK-mediated filopodial pathfinding facilitates midgut elongation. Development, Oct 27;147(20):dev195388
Badu-Nkansah, K. and Lechler, T. 2020. Proteomic analysis of desmosomes reveals novel components required for epidermal integrity. Molecular Biology of the Cell, pp.mbc-E19.
Moreci, R.S. and Lechler, T. 2020. Epidermal structure and differentiation. Current Biology, 30(4), pp.R144-R149. doi: 10.1016/j.cub.2020.01.004.
Morrow, A., Underwood, J., Seldin, L., Hinnant, T., & Lechler, T. 2019. Regulated spindle orientation buffers tissue growth in the epidermis. eLife, 8. doi: 10.7554/eLife.48482.
Sumigray K, Lechler T. 2018. Cellular Dynamics Driving Elongation of the Gut. Developmental Cell. Jul 16;46(2):127-128. doi: 10.1016/j.devcel.2018.06.027.
Muroyama A, Terwilliger M, Dong B, Suh H, Lechler T. 2018. Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport. Mol Biol Cell. Jul 1;29(13):1533-1541. doi: 10.1091/mbc.E18-01-0057.
Sumigray K, Terwilliger M, Lechler T. 2018. Morphogenesis and Compartmentalization of the Intestinal Crypt. Developmental Cell. Apr 23;45(2):183-197.e5. doi: 10.1016/j.devcel.2018.03.024.
Muroyama A, Lechler T. 2017. A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis. Elife Sep 4;6. pii: e29834. doi: 10.7554/eLife.29834.
Muroyama A, Lechler T. 2017. Microtubule organization, dynamics and functions in differentiated cells. Development. Sep 1;144(17):3012-3021. doi: 10.1242/dev.153171.
Lechler T, Carazo Salas RE. 2017. Editorial overview: Cell architecture: Mechanisms and scales of cellular organization and decision making. Curr Opin Cell Biol. Feb;44:iv-v. doi: 10.1016/j.ceb.2017.03.009.
Muroyama A, Seldin L, Lechler T. 2016. Divergent regulation of functionally distinct γ-tubulin complexes during differentiation. J Cell Biol. Jun 20;213(6):679-92.
Seldin L, Muroyama A, Lechler T. 2016. NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures. eLIFE Jan 14;5 pii: e12504. doi: 10.7554/eLife.12504.
Zhang X, Wu J, Luo S, Lechler T, Zhang JY. 2016. FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms. Oncotarget. 2016 Apr 29.
Morrow A, Lechler T. 2015. Studying cell biology in the skin. Mol Biol Cell. 2015 Nov 15;26(23):4183-6. doi: 10.1091/mbc.E15-04-0246.
Sumigray KD, Lechler T. 2015. Cell adhesion in epidermal development and barrier formation. Curr Top Dev Biol. 2015;112:383-414.
Lechler T. Arp2/3 complex function in the epidermis. 2014. Tissue Barriers. Aug 8;2(4):e944445.
Sumigray K, Zhou K, Lechler T. 2014. Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. PLoS One. Jul 9;9(7):e101824.
Seldin L*, Poulson ND*, Foote HP and Lechler T. 2013. NuMA localization, stability and function in spindle orientation involve 4.1 and Cdk1 interactions. Molecular Biology of the Cell, 24:3651-3662.
Zhou K*, Muroyama A*, Underwood J, Leylek R, Ray S, Soderling SH and Lechler T. 2013. Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci, 110:E3820-E3829.
Foote HP, Sumigray KD and Lechler T. 2013. FRAP Analysis Reveals Stabilization of Adhesion Structures in the Epidermis Compared to Cultured Keratinocytes. PLoS One, 8:e71491.
Ray S*, Foote HP* and Lechler T. 2013. beta-Catenin protects the epidermis from mechanical stresses. Journal of Cell Biology, 202:45-52.
Sumigray KD, Foote HP and Lechler T. 2012. Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation. Journal of Cell Biology, 199:513-525.
Muroyama A. and Lechler T. 2012. Polarity and Stratification of the Epidermis. Seminars in Cell and Developmental Biology, 23:890-896.
Lechler, T. 2012. Adherens Junctions and Stem Cells. Subcellular Biochemistry, 60:359-377.
Sumigray KD and Lechler T. 2012. Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium. Molecular Biology of the Cell, 23:792-9.
Poulson ND and Lechler. 2012. Asymmetric cell divisions in the epidermis. Int Rev Cell Mol Biol., 295:199-232.
Sumigray KD, Chen H, and Lechler T. 2011. Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. Journal of Cell Biology, 194:631-42.
Sumigray KD and Lechler T. 2011. Control of cortical microtubule organization and desmosome stability by centrosomal proteins. Bioarchitecture, 1:221-224.
Ray S and Lechler T. 2011. Regulation of asymmetric cell division in the epidermis. Cell Division, 6:12.
Poulson ND and Lechler T. 2010. Robust control of mitotic spindle orientation in the developing epidermis.Journal of Cell Biology, 191:915-22.
Sumigray KD and Lechler T. 2010. Dissecting cell adhesion cross-talk with micropatterns. Proc Natl Acad Sci, 107:13199-200.
Lechler T. 2008. Limiting lumens: a new role for Cdc42. Journal of Cell Biology, 183:575-7.
Previous Work
Lechler T. and E. Fuchs. 2007. Desmoplakin: An unexpected regulator of microtubule organization in the epidermis.. Journal of Cell Biology, 176:147-54.
Lechler T. and E. Fuchs. 2005. Asymmetric cell divisions promote stratification and differentiation of mammalian skin.. Nature, 437:277-280.
Kodama A, T. Lechler, and E. Fuchs. 2004. Polarizing cytoskeletal networks for directed cell migration. Journal of Cell Biology, 167:203-207.
Tinkle CL*, Lechler T*, Pasolli HA, Fuchs E. 2004. Conditional targeting of E-cadherin in skin: Insights into hyperproliferative and degenerative responses. Proc. Natl. Acad. Sci. USA, 101:552-557.
Kodama A, Lechler T, and Fuchs E. 2004. Coordinating cytoskeletal tracks to polarize cellular movements.Journal of Medicinal Chemistry, 39:3984-97.
Yarrow, J., T. Lechler, R. Li. T. J. Mitchison. 2003. Rapid de-localization of actin leading edge components with BDM treatment. BMC Cell Biol, 4.
Soulard, A., T. Lechler, V. Spiridonov, A. Shevchenko, A. Schevchenko, R. Li, and B. Winsor. 2002. Saccharomyces cerevisiae Bzz1p is Implicated with Type I Myosins in Actin Patch Polarization and is Able to Recruit Actin-Polymerizing Machinery In Vitro. Mol. Cell. Biol., 22:7889-96.
Lechler, T., G.A. Jonsdottir, S.K. Klee, D. Pellman, and R. Li. 2001. A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. Journal of Cell Biology, 155:261-70.
Egile, C., T. Lechler and R. Li. 2001. Beyond a Skeleton: understanding cellular functions of the cytoskeleton. Genome Biology, 2:4005.1-3.
Lechler, T., A. Shevchenko, A. Shevchenko, and R. Li. 2000. Direct Involvement of yeast type I myosins in Cdc42-dependent actin polymerization. Journal of Cell Biology, 148:363-373.
Winter, D.*, T. Lechler*, and R. Li. 1999. Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein. Current Biology, 9:501-504.
Xiao, W., T. Lechler, B. L. Chow, T. Fontanie, M. Agustus, K. C. Carter, and Y. F. Wei. 1998. Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase zeta. Carcinogenesis, 19:945-9.
Lechler, T.., and R. Li. 1997. In vitro reconstitution of cortical actin assembly sites in budding yeast. Journal of Cell Biology, 138:95-103.
Dimmock, J. R., R. N. Puthucode, J. M. Smith, M. Hetherington, J. W. Quail, U. Pugazhenthi, T. Lechler, and J. P. Stables. 1996. (Aryloxy)aryl semicarbazones and related compounds: a novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen. Journal of Medicinal Chemistry, 39:3984-97.
* denotes co-authorship